Doctor Frog to the Rescue!
Scientists are finding new ways to treat sick people by studying frogs!
This is yet another good reason to be concerned about the fate of our worlds frogs since every day so many frogs are threatened by environmental problems! For example, scientists found a way to make a new drug painkiller from the toxins in a frog's skin. The frog (Epibpedobates tricolor) is found in Ecuador. Poison in its skin protects it from predators. They couldn't use the poison itself for humans because it's too powerful (isn't that amazing?), but researchers took the frog poison (its structure) as a model for this new drug.
Frog-Skin Poison Could Yield New Painkiller (article from 1997) WASHINGTON (Reuters) - A lethal poison in the skin of an Ecuadorean frog could lead to a painkiller that may be stronger than morphine but without morphine's side-effects, researchers reported Friday. The new drug, known as ABT-594, would target the same kinds of severe pain now treated by morphine, including pain associated with some cancers and traumatic injury. The compound, developed by researchers at Abbott Laboratories, has shown promise for pain relief in rats and mice, and is currently being tested on humans in Europe to determine its safety, Dr. Michael Williams of Abbott said in a telephone interview. The compound is similar to substances found in the skin of an Ecuadorean frog, which relieves pain but also causes hypertension, neuromuscular paralysis and seizures. The researchers were able to isolate the pain-relieving properties without including the deadly ones. Williams stressed that research into the new painkiller was at an early stage, with preliminary human trials currently proceeding in Europe and no estimate of when such a drug might get to market. However, he said that in tests on animals, there was no sign of addiction, an important advantage over morphine. Some 30 million to 40 million Americans use morphine to relieve pain, despite serious side effects including respiratory depression, dangerous constipation and addiction, according to the journal Science, which published the research. |
Frozen Frog May Give Docs Jump on Human Transplants Brian Handwerk for National Geographic News March 1, 2005 The common wood frog displays a rare trait called freeze tolerance. When the mercury falls, the animal becomes, to the eye and touch, a frog- shaped ice cube. The way it does this may eventually be copied to aid human organ transplants. "Two-thirds of their body water, or more, freezes," explained Jack Layne, a biologist at Slippery Rock University of Pennsylvania. "The heart stops, the breathing stops. For all practical purposes you'd assume that it was dead." In reality, the frog's metabolism slows to a crawl, and its body temperature drops to between 21� and 30� Fahrenheit (�6� and �1� Celsius). The amphibian's heart and brain cease to function. Frozen frog experts, such as biochemists Ken and Janet Storey of Carleton University in Ottawa, Canada, believe the animals acquired their ability to withstand a deep freeze about 15,000 years ago, during ice age evolution.
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